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Both LRP6 function as a Wnt co-receptor for Fz proteins and DKK-1 inhibition of Wnt signaling by preventing Fz-LRP6 complex formation seem to be specific for Wnt/Fz signalling toward the -catenin pathway [65]

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The crystal structure of the hNNMT-NAM-SAH ternary complex at 2.7 was first determined by Emanuelli using X-ray crystal diffraction