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Conjugation The elimination of many xenobiotic compounds can be accomplished through conjugation with GSH followed by secretion of the adduct from the cell (Boyland and Chasseaud 1969)

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Further, in 2022, Colorados drug overdose death rate was 29.8 per 100,000, and has continued to climb annually, with fentanyl-involved deaths increasing 18.4% in 2023 (Centers for Disease Control and Prevention., n.d.)

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