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Male C57BL/6 mice (78 weeks old, 2528 g) were purchased from the Institute of Laboratory Animal Science at the Chinese Academy of Medical Sciences (Beijing, China) and housed in a specific pathogen-free facility maintained at 2022 C, with cycles of 12 h light-dark and food and water ad libitum

[ 411 ] Hyperglycemia/high glucose increases BACH1 expression in the aorta of diabetic rats, and BACH1 accelerates hyperglycemiainduced EndMT via facilitating AKT3 transcription, promoting diabetic cardiovascular complications