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doi: 10.3389/fphar.2019.01327 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.Tallarida RJ

M1 is a macrophage phenotype that prolifically produces proinflammatory cytokines, such as TNF and IL6 [9]

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This system comprises nerve structures beyond the brain and spinal cord that communicate with the rest of the body