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Phase II transformations generate highly polar derivatives (conjugates), such as glucuronides and sulfate esters, which are excreted into the urine

Three prominent examples include, (i) phosphorylation and recruitment of voltage-gated Ca2+ channels in heart to increase contractility, (ii) phosphorylation of phosphorylase kinase, which in turn phosphorylates phosphorylase, which releases glucose-1-phosphate from glycogen and boosts energy metabolism in liver, and (iii) response to odorants by sensory neurons in the olfactory epithelium by direct action of cAMP on opening of cAMP-gated ion channels of the plasma membrane of olfactory neurons