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During parasitemia, upon degrading the erythrocyte, ferriprotoporphyrin IX (hemozoin) becomes toxic to the parasite, which, using the polymerization process, converts it into an inert pigment, hemozoin

Wenn zu viele dieser aggressiven Teilchen vorhanden sind und nicht neutralisiert werden knnen, entsteht oxidativer Stress

WEHI, 32D (32Dcl3), WT, T315I-BcrAbl-transformed 32D, and TCCS cells were maintained in RPMI 1640 medium (Sigma) supplemented with 10% heat-inactivated FBS, 1% Streptomycin/Penicillin, 1 mM sodium pyruvate, and 10 mM HEPES

It inhibits the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) [200], a crucial factor in the regulation of inflammation and immune responses, thereby reducing the expression of proinflammatory cytokines, including IL-6, IL-1, and TNF- [182, 185]

Nucleic Acids 35 , 102111 (2024)

Aging Cell 4 , 119125 (2005)