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Description
These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

27 , 10671080.e5 (2018)

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It allows the B12 to bind to fat molecules and be released slowly into body tissues

Like headaches, this tends to occur early in use and resolve as the body adjusts

In these cases, tiaminal B12 injection is a good way to get enough B12 without going through the digestive system
