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The addition of equimolar or higher concentrations of Cu 2+ to Htt induces oligomerization, along with the rapid reduction of Cu 2+ to Cu 1+ ( 2+ to Cu 1+ , and copper promotes its aggregation, mediated by histidine residues ( Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt

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