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K., Geier D

361,390 Among the kinases recognized to phosphorylate and activate HSF1 are EEF2K (alias CaMKIII), mTORC1, MAP2K1/-2 (alias MEK1/-2), MAPK14 (p38 MAPK), and PLK1, suggesting that HSF1 activation may be regulated by calcium signaling, energy and nutrient availability, as well as growth factors, cytokines, and other extracellular signaling molecules, including possible coordination with the cell cycle

For example, various signaling pathways directly facilitate drug-induced ferroptosis, thereby impeding CRC onset and progression

Cancer Cell , 21 (3), 297308

doi:10.3109/14756366.2010.526769

Hum Brain Mapp 41(4):10171029