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The Keap1Nrf2ARE pathway (Kelch-like ECH-associated protein 1Nuclear factor erythroid 2Antioxidant Response Element), transiently activated during ovulation and implantation, induces antioxidant enzymes such as HO-1 (heme oxygenase-1) and NQO1 (NAD(P)H:quinone oxidoreductase 1), thereby providing cytoprotection without suppressing the physiological ROS signaling essential for fertilization and embryo development (6064)

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for a detailed review of STDP, see Caporale and Dan, 2008 )

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