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doi: 10.3389/fonc.2024.1399021 25 HeCWuTHaoY
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Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)
Therefore, further refinement can be introduced
Doktorova M, Levine MV, Khelashvili G, Weinstein H (2019) A New computational method for membrane compressibility: bilayer mechanical thickness revisited
