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QZ and XZ wrote and revised the manuscript

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While the primary mechanisms of CPZ toxicity are poorly understood, in vitro studies report CPZ toxicity to be limited to primary oligodendrocytes (Bnardais et al., 2013) while others suggest the requirement of pro-inflammatory cytokines (Pasquini et al., 2007)

[178] [168] however, when administered with paracetamol (acetaminophen) tramadol provides short-acting mechanical antinociception [176] [168] and when administered with ketamine oral tramadol provides adequate analgesia for chronic laminitis