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A study examining the pharmacokinetics of benfotiamine treatment in Alzheimer's patients showed that maximum thiamine concentrations in the blood were reached 12h after a single dose of benfotiamine, while ThMP and ThDP peaked at later time points, between 3,5 and 8h for ThMP and 824h for ThDP

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J Neuropathol Exp Neurol 62:475485 van Landeghem FK, Stover JF, Bechmann I, Bruck W, Unterberg A, Buhrer C, von Deimling A (2001) Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat