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However, autologous plasma may lack sufficient levels of key neuroprotective factors due to age or diseaserelated declines, potentially limiting its therapeutic efficacy [297]

Zhao N, Lu XL, Li JT, Zhang JM

(2022) 43:P7884

Exenatide is studied in laboratory models involving GLP-1 receptor pathway activity, incretin signaling, glucose-response biology, pancreatic beta-cell signaling, metabolic regulation, gastric-emptying pathway research, and energy-balance systems

81 , e00036-17 (2017)

Since then, other numerous genetic alterations in SNCA (single-point mutations, duplications, and/or triplication) [39,40,41,42,43,44,45] and other genes ( GBA , PINK1 , LRRK2 , Parkin, or DJ1 , among others) [46,47,48,49] gradually appeared as risk factors of PD early onset and progression, opening up possibilities for the development of genetic models that recapitulate the molecular origin the disease better than the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA) neurotoxin ones do [50]