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It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use

therefore, no cosmetic brightening treatment can ever be defined as permanent

2013;8(9):e72995

Finally, sixty-eight participants completed the study (PD, N = 38 and HC, N = 30) and their data was included for final analysis

doi: 10.3390/ijms242115596

Effect of cigarette smoke on UDP-glucuronosyltransferase activity and cytochrome P450 content in liver, lung and kidney microsomes in mice