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The Two Main MTHFR SNPs Genetic variations in the MTHFR gene results in reduced activity of the enzyme produced and have been associated with a series of diseases and conditions, including cardiovascular disorders, neurological defects, some forms of cancer, psychiatric disorders, diabetes, and pregnancy complications [3, 4]

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PubMed,

The findings reveal that icariin reduces the atherosclerotic plaque area and collagen fibers in aortic sinus tissue while enhancing mitochondrial activity and membrane potential

Safety, pharmacology, and preliminary clinical activity of MM-151: an oligocolnal anti-EGFR theraputic in patients with cetuximab-resistant CRC and other refractory solid tumors