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In agreement with this, treatments for some IEMs aim to mitigate overstimulation of N-methyl-D-aspartate (NMDA) receptors by NMDA receptor antagonists and to reduce the levels of the accumulated metabolites that activate these receptors

Biochemical assessments measured oxidative stress markers [superoxide dismutase (SOD), catalase, and glutathione (GSH)], proinflammatory cytokines (TNF, IL-6, and IL-1), and brain monoamines [dopamine (DA) and acetylcholine (ACh)]

It is widely utilised in endocrine and neuroendocrine research due to its role in pituitary signalling and growth hormone axis investigations

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