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Once B12 deficiency has been identified and treatment commenced, it is important to allow sufficient time for red blood cell populations to normalise before repeating HbA1c testing

Stastistical analysis For analysis of distribution normality in vivo and in vitro acquired data Kolmogorov-Smirnov test was used

Growth hormone insensitivity

Apart from soluble factors derived from MSCs, such as TGF-1, PGE2, IDO, and HO-1 [160, 171, 172], direct contact, especially via Notch signaling, also plays a pivotal role in MSC-mediated T reg induction [173]

Abbreviations HGF: hepatocyte growth factor ICIs: immune checkpoint inhibitors TME: tumor microenvironment EMT: epithelial-mesenchymal transition HNSCC: head and neck squamous cell carcinoma RTKs: receptor tyrosine kinases METex14: MET exon 14 skipping mutations NSCLC: non-small cell lung cancer CAFs: cancer-associated fibroblasts TAMs: tumor-associated macrophages MDSCs: myeloid-derived suppressor cells NK: natural killer DCs: dendritic cells ECM: extracellular matrix Chi3L1: chitinase-3-like-1 Treg: T regulatory CRC: colorectal cancer GC: gastric cancer IL-6R: interleukin-6 receptor MMPs: matrix metalloproteinases HIF1: hypoxia-inducible factor 1 IFN-: interferon-gamma HCC: hepatocellular carcinoma CTLs: cytotoxic T lymphocytes MSCs: Mesenchymal stromal cells CTLA-4: cytotoxic T-lymphocyte-associated protein 4 APCs: antigen-presenting cells ORR: objective response rate PFS: progression-free survival OS: overall survival GSK3: glycogen synthase kinase 3 References Knowles LM, Stabile LP, Egloff AM, Rothstein ME, Thomas SM, Gubish CT, Lerner EC, Seethala RR, Suzuki S, Quesnelle KM, et al

Therefore, future therapeutic paradigms must shift toward precision medicine, leveraging integrated high-throughput technologiesincluding single-cell sequencing, spatial transcriptomics, proteomics, and metabolomicsto systematically decipher patient-specific molecular profiles and dynamic signaling networks of macrophages in particular disease states