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Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

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To proceed, we used RF and XGB algorithms, which are broadly used to predict pKa, and trained them using our own dataset and a variety of molecular descriptors or fingerprints (2D molecular descriptors, Estate, EstateSum, MACCS, 2D and MACCS combined, and Morgan fingerprints, Fig