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Eur Neuropsychopharmacol
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Moreover, Mendelian randomization analyses suggest a causal contribution of elevated urate to fibrosis and HCC [121, 124, 125]
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CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle
Skipping this step can lead to issues if B12 levels arent where they need to be, resulting in potential side effects or a deficiency relapse
