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doi: 10.1016/j.ijscr.2023.108166 215

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Bauman JE, Hsu CH, Centuori S, et al

Nanoparticles have the capability to effectively transport medications or gene fragments to tumor tissues via passive or active targeting processes, thus enhancing treatment outcomes while minimizing harm to healthy tissues
Mol Ther 14 : 571577
Furthermore, any intact glutathione that does manage to cross the intestinal wall is immediately routed to the liver via the portal vein, where it is subjected to heavy "first-pass metabolism." Because of this rigorous digestive and hepatic breakdown, early pharmacokinetic studies demonstrated that standard oral glutathione often fails to significantly boost serum or intracellular levels, rendering many traditional, over-the-counter supplements highly ineffective for chronic illness management