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Beyond dietary modifications, LC-FAOD (VLCAD [very long-chain acyl-CoA dehydrogenase], MTP/LCHAD, CACT [carnitine acylcarnitine translocase], CPT IA, CPT II) can be effectively and safely treated with an anaplerotic drug, triheptanoin

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While both compounds improve these metrics, the magnitude of change in retatrutide trials has led some researchers to suggest it may provide a more potent "reset" of metabolic syndrome markers

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These patients underwent contrast-enhanced dynamic magnetic resonance imaging (Yang et al