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Plateau effects sometimes occur after initial rapid improvement

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Risk Management & CAPA Linkage FDA expects firms to connect the dots. Risk assessments must be robust, and CAPAs must address root causes and systemic issues, not just isolated events

A notable pattern also emerged around other reward-seeking behaviours: a significant proportion of participants noticed reduced interest in alcohol, impulsive purchasing, and other dopamine-driven activities

Offer quiet activities and a cool compress if they find that soothing

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