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Off-the-shelf, steroid resistant, IL13Ralpha2- specific CAR T cells for treatment of glioblastoma
10.3389/fimmu.2018.00855 24 ChangY
In the case of I/R injury, systemic inflammation and the release of cytokines and LPS can enhance BBB permeability by breaking tight junctions between endothelial cells and by activating matrix metalloproteinases that breakdown the extracellular matrix (S-Pereira et al., 2012)

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Furthermore, aberrant vasculature promotes the Warburg effect, which accumulates lactic acid within the TME, which is another important cause of suppressed anticancer immunity [36,68]

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