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The bioinformatics tools and technologies in drug discovery mainly include biological databases (Table 1), computer-aided drug design (CADD) and omics technologies (see the omics strategies section) (Zhang et al., 2025)

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3 Study progress of NNMT in MetS-related diseases Metabolic Syndrome (MetS) represents a constellation of metabolic disorders arising from intricate interplays between genetic predisposition and environmental influences

The gut microbiota influences selenium metabolism and absorption in the colon (36)

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4) The following applied to female patients only: non-pregnant, non-lactating females of childbearing potential who agreed to use medically acceptable forms of birth control from screening until the end of study