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doi:10.1016/j.cotox.2017.10.008

The first reported GHR antagonist was a bovine GH protein that was mutated with three amino acid substitutions located in helix 3, which resulted in a dwarf phenotype in transgenic mice

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This study used the NNMTi 5-amino-1-methylquinolinium (5A-M1Q), since our lab has set precedence using this probe molecule for proof-of-concept studies 8

Used together, the effect exceeds either alone the most common pairing in the field

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