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Side effects of these medications range from hypersensitivity reactions, increased risk of enteric infections, decrease of vitamin absorption up to dementia, and an elevated risk for gastric cancer (Ahmed 2020

Based on the existing research, it is speculated that it may play an anti-inflammatory effect by inhibiting the inflammatory response pathway ( Figure 2 Figure 3 It is worth noting that due to the lack of standardized processing, quality of quality of Chinese herbal medicine, and potential drug interactions, some Chinese herbal preparations may have efficacy and safety issues ( 3 Acupuncture therapy and its effect Acupuncture originated in China and has a history of more than 3,000 years ( Figure 4 ) Figure 4 From 2020 to 2022, a large number of articles proving the effectiveness of acupuncture in the treatment of primary dysmenorrhea were been published (53)

Therefore, low cellular energy states will lead to induction of 2-oxoglutarate production via the glutamate dehydrogenase reaction allowing for increased ATP synthesis from the TCA cycle-derived NADH and FADH 2