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This protein kinase is a downstream target of oxidative stress and proinflammatory cytokines and its activation can increase vascular permeability and cell death, the key elements of diabetic retinopathy pathogenesis [142]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Sadowska A.M., Manuel-y-Keenoy B., Vertongen T., Schippers G., Radomska-Lesniewska D., Heytens E., De Backer W.A

In contrast, abundant evidence demonstrates that enhancing Nrf2 signaling is potently neuroprotective in models of neurodegeneration, although the exact mechanism by which this is achieved is unclear