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The antioxidant effects of NRF2 are mediated not by direct ROS scavenging, but by transcriptional upregulation of an integrated network of cytoprotective genes that enhance ROS neutralization and redox homeostasis

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doi: 10.1016/j.joca.2019.02.369 31 ValdianiATaleiDLattooSKOrtzRRasmussenSKBatleyJet al

C R Seances Acad Sci III 292:793796 Davis SL, Safieh-Garabedian B, Khosraviani M (1994) Concentrations of thymulin in unextracted serum from pigs, sheep and cattle as measured by ELISA

Notably, in Arabidopsis thaliana the mutation of arGST tt19 completely eliminates production of epicatechin 34 an unexpected outcome in the frame of the ligandin model as the cytosolic availability of cyanidin ( 8-AH + ), the precursor molecule of epicatechin ( 19 ), should be unaffected by mutating a transport protein