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With glucose metabolizing into pyruvate, it enters the mitochondria and participates in the tricarboxylic acid cycle (TCA), where reduced nicotinamide adenine dinucleotide (NADH) and reduced flavin adenine dinucleotide (FADH 2 ) are produced and then go through the respiratory chain pushing the adenosine triphosphate (ATP) pump to produce large amounts of ATP

10.1093/HUMREP/DEH698 9 AtkinsonC.LampeJ

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Neuro-oncology (2016) 18(6):80718

In addition, there are several other stress kinases that were found to regulate NRF2 nuclear localization by phosphorylation, including the ER stress kinase PERK and the energy sensor AMPK [13, 14]

Antioxidant glutathione inhibits inflammation in synovial fibroblasts via PTEN/PI3K/AKT pathway: an in vitro study