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Further study also is needed to understand how NNMT inhibits the formation of NAD + in adipose tissues and why there are redundant regulatory pathways for the metabolism of NAD + in livers

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As shown in Table 1 and Figure 6, in the pursuit of structurally diverse NNMT inhibitors, researchers have identified certain macrocyclic peptides that bind to NNMT, displaying potent inhibition with Half-maximal inhibitory concentration (IC 50 ) values as low as 229 nM (Van Haren et al., 2021)