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During the deep stages of rest, the liver works hard to process waste, and cells regenerate

The FDA has granted Generally Recognized as Safe (GRAS) status to glutathione when used in food products

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The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

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