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The UHPLC was equipped with a 5 L loop, and reversed-phase chromatographic separation was performed using a nanoflow column (50 cm75 m ID, New Objective, Woburn, MA) self-packed with Luna C18 (5 m,100 , Phenomenex)

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Diabetes 51 , 22412248 (2002)

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Further experiments showed that even after repeated exposure to the drugs, the researchers were able to reverse this neurotransmitter switch using molecular tools to locally decrease the brains electrical activity or using clozapine, an antipsychotic drug