glutathione shunt production and turnover in RBC. Schematically presented are Glutathione Metabolism - an overview

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( g ) Representative histograms showing CD44 expression on splenic stromal fibroblastic cells (FC), endothelial cells (EC) and dendritic cells (DC) isolated using a stromal isolation protocol

DOI: 10.1371/journal.pone.0130189 58

doi:10.3390/ph18020185

Importantly, serum B12 levels can be misleadingly normal or even elevated in chronic liver disease due to increased levels of binding proteins (such as haptocorrin) and reduced clearance, meaning that total B12 measurements may not accurately reflect tissue B12 status or functional deficiency

More severe disease is associated with progressive destruction and loss of elastin, smooth muscle, mucous glands and cartilage