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[DOI] [PubMed] [Google Scholar] 39.Boozer CN, Leibel RL, Love RJ, Cha MC, Aronne LJ

In contrast, the -arrestin 1-biased agonist R399 activated YAP, promoting NSCLC growth (95), suggesting a therapeutic window for Gs-biased TGR5 agonists

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For instance, in T cells, stimulation leads to ROS generation and activation of the NRF2 pathway

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