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Ann Hum Genet
Trichostatin A, an histone deacetylase inhibitor that increases H3K27ac (24), significantly induced Spp1 mRNA levels in hepatocytes isolated from WT Cebpa fl/fl mice and restored the Ad-CEBPA-downregulated Spp1 mRNA (Supplemental Figure 6E), while trichostatin A failed to further enhance Spp1 mRNA levels in hepatocytes isolated from Cebpa Hep mice (Supplemental Figure 6F)
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A separate 2017 trial found that participants receiving lipotropic injections had an average 2.9 cm greater reduction in waist circumference after 6 weeks compared to the placebo group
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