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Description
The GM metabolite TMAO inhibited Cytotoxicity through activation of the nuclear receptors Farnesoid X receptor (FXR) and small heterodimer partner (SHP) to inhibit the expression of Cyp7a1, an enzyme that plays a key role in cholesterol metabolism and bile acid synthesis, reducing hepatic BA synthesis, accelerating the development of AS, and decreasing reverse cholesterol transport [61], providing further evidence of the link between gut microbiota and AS (Table 1)

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the other was a prospective observational design
doi: 10.1016/S0196-9781(00)00165-0 24 BagheriS.SabouryA
