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Targeting mitochondrial dysfunction and oxidative stress to prevent the neurodegeneration of retinal ganglion cells

(PubMed) Gomez-Sierra T, Molina-Jijon E, Tapia E, et al

PMID: 32753105

The complete sequence of this research compound is: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, with a disulphide bond between the two cysteine residues (Cys-7 and Cys-15) that contributes significantly to the structural stability of the peptide loop conformation

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Organic solvent in the incubations was limited to 0.01% dimethylsulfoxide (DMSO) and 1% acetonitrile