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Although some approved drugs such as metformin and propofol have been shown to induce ferroptosis, their primary therapeutic roles lie outside of ferroptosis induction, and the activation of other pathways by these drugs may lead to significant side effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Tew K.D

Liu G, Cheng J, Zhang T, et al

demonstrated how melatonin enhanced the HAT activity of CPB/p300 histone proteins in the MAPK/ERK1/2 signaling pathway on neuronal stem cells correcting the abnormal phosphorylation through acetylation of histone proteins at lysine 14 (H3K14) (Li et al., 2017a), thus reducing the hyperphosphorylated effects on tau

10.1016/j.bbcan.2020.188427 215 KhanH.PatelS.MajumdarA