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Their role in cancer is seen as intercellular communication, promotion of signal transduction as well as the transfer of membrane receptors, proteins, mRNA, and miRNAs between cells and this contributes to tumorigenesis, metastasis, and chemo-resistance (Urbanelli et al., 2013)

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Those which have a lower affinity for metal ion, but still require the metal ion for activity, are known as metal-activated enzymes

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