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Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions

BPC-157 is a synthetic 15-amino-acid peptide derived from a naturally occurring protein fragment found in human gastric juice.

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doi:10.1016/j.cmet.2020.03.004 Fanelli S, Francioso A, Cavallaro RA, dErme M, Putignano P, Miraglia N, et al

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