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L-carnitine is responsible for shuttling fatty acids from the cytosol into the mitochondria for fatty acid -oxidation and energy production [2]

Internal wellness also plays an important role

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With concurrent downregulation of ferroportin (FPN) and iron-regulating proteins (IRP1/2), M1-polarized macrophages show increased hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL) relative to their M2 counterparts (96)

Factors like stress, poor diet, environmental toxins, and illness can further deplete these levels, creating a need for additional support through supplementation