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Both smokers and passive smokers have lower plasma and leukocyte vitamin C levels than non-smokers [10,210,211], partly due to increased oxidative stress and to both a lower intake and a higher metabolic turnover of vitamin C compared to non-smokers [10,211,212,213]

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Second, as an adaptive stress resistance mechanism, HIF-1 activates autophagy by upregulating BNIP3, facilitating the removal of damaged organelles such as mitochondria 94

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