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IGF-1, as happens with other hormone therapies (thyroid hormone or insulin), should never been used lightly without firstly assessing its deficiency (local, central or systemic) and secondly by ascertaining that no tumours are near to be generated

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and the hGH Biomarkers Test that is based on the measurement of IGF-1 and the N-terminal pro-peptide of type 3 collagen (P-III-P) as two markers shown to increase in a dose-dependent manner following GH administration [100]