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These findings lead us to hypothesize that the reduction in TGF-1 secretion by ECs, which subsequently affects CFs, may be the primary mechanism underlying the PD-1 inhibitor-induced decrease in cardiac interstitial collagen

DNA repair Mutation in gene encoding enzymes involved in DNA damage response (DDR) such as ataxia telangiectasia (ATM), ATR, RAD50, and WRN can enhance the risk of cancer emergence and resistance [56]

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Plant J 49:159172 Park SI, Kim YS, Kim JJ, Mok JE, Kim YH, Park HM et al (2017) Improved stress tolerance and productivity in transgenic rice plants constitutively expressing the Oryza sativa glutathione synthetase OsGS under paddy field conditions

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