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Glutathione S -transferases A family of enzymes that catalyzes the reaction of the cysteinyl anion of glutathione with an electrophile generating the corresponding glutathione S -conjugate

Discussion In this study, we unveiled the metabolic reprogramming of cancer cells lacking HIF1 or HIF2 expression in normal oxygen conditions and in response to irradiation

With respect to fatty acid metabolism, CYP2E1 catalyzes the microsomal (-1)- and (-2)-hydroxylation of saturated fatty acids and the epoxidation of unsaturated fatty acids

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The ongoing phased replacement of older, more toxic NRTIs (e.g., d4T, AZT) with newer agents such as tenofovir alafenamide (TAF) and integrase strand transfer inhibitors (INSTIs), which have minimal impact on mtDNA, is a critical step in mitigating iatrogenic mitochondrial harm (164166)

They are not a fly-by-night operation