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In some extreme cases, there has been evidence of tingling sensation and even chest pains in those lacking B12

doi:10.1016/j.ecoenv.2020.110462

[132] proposed that if an individual is deficient in a specific nutrient, supplementation with that specific antioxidant may be warranted and could support performance-related outcomes

It directly binds to Nrf2 and promotes GPX4 transcription, which in turn inhibits ferroptosis after IRI and ameliorates brain damage (Choi et al., 2023)

doi: 10.1016/S0022-0728(01)00517-4

vi) SNO intermediates: GSNO facilitates the conversion of thiol-nitrosylated proteins (P-SNO) to SSG (17)