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Cysteine restriction promotes an iron-dependent form of cell death known as ferroptosis 7 , where Fenton chemistry promotes the generation of free radicals that initiate lipid radical formation and the unsustainable peroxidation of plasma membrane phospholipids 8

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Caimi PF, Ai W, Alderuccio JP, Ardeshna KM, Hamadani M, Hess B, et al

Inomata et al

Electrophoresis 37 (1), 86110

612,615 Therefore, the identification of the putative NMN transporter and its tissue specific expression pattern will help assess the cell type or tissue-specific preference of NMN, paving the way for precious clinical application of NMN in different conditions