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Subsequently, STATs are phosphorylated and translocated into the nucleus, where they enhance the transcription of target genes (including TGF- , TNF- , IL-2 , IL-6 , IL-8 , MMP9 , Intercellular Adhesion Molecule 1 ( ICAM-1 / CD54 ), STAT1 , and STAT3 ) (81)

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The peptides controlled copper delivery ensures optimal enzyme function for proper collagen architecture, creating the strong, resilient tissue matrix characteristic of healthy, youthful skin