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On this basis, a specific subset of T cells with elevated expression of CD28 (a costimulatory molecule required for T cell activation) is capable of maintaining robust telomerase activity upon stimulation 379

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Cancerous tumors require significant levels of cysteine and GSH to counteract the increased intracellular ROS and nutritional dependency required for the enhanced action of SLC7A11 (46)

185 Besides, ROS-driven JAK/STAT signaling upregulates Z-DNA binding protein 1 (ZBP1), which forms a complex with RIPK3 in the absence of RIPK1, triggering MLKL-mediated necroptosis

[DOI] [PubMed] [Google Scholar] He X, Semenov M, Tamai K, Zeng X